Santa Casa da Misericórdia (House of Mercy) in Cochin was a charitable institution founded by the Portuguese in 1524. It was located near the Santa Cruz Cathedral Basilica, which is one of the oldest churches in Cochin and India. The Santa Casa da Misericórdia provided medical care, education, and social services to the poor and needy. It also had a chapel dedicated to Our Lady of Mercy. The institution was supported by donations from the Portuguese crown, nobles, and merchants. It was administered by a brotherhood of laymen who followed the rule of St. Francis of Assisi.

The Santa Casa da Misericórdia was destroyed by the Dutch in 1663, when they captured Cochin from the Portuguese. The Dutch also demolished the original Santa Cruz Cathedral, which was rebuilt later by the British. The Santa Casa da Misericórdia was never restored, and its exact location is unknown today. However, some historians believe that it was situated near the Parade Ground in Fort Kochi, where a memorial plaque has been erected. You can see a picture of the plaque here: Memorial plaque of Santa Casa da Misericórdia in Santa Cruz Basilica.